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72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. [5] The MMP2 gene is located on chromosome 16 at position 12.2.
The active site is a 20 Å (2 nm) groove that runs across the catalytic domain. In the part of the catalytic domain forming the active site there is a catalytically important Zn 2+ ion, which is bound by three histidine residues found in the conserved sequence HExxHxxGxxH. Hence, this sequence is a zinc-binding motif.
234911 Ensembl ENSG00000137675 ENSMUSG00000070323 UniProt Q9H306 n/a RefSeq (mRNA) NM_022122 NM_001030289 NM_001310717 RefSeq (protein) NP_071405 n/a Location (UCSC) Chr 11: 102.69 – 102.71 Mb Chr 9: 7.57 – 7.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metallopeptidase 27 also known as MMP-27 is an enzyme which in humans is encoded by the MMP27 gene. Structure MMP ...
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria. [ 5 ] Members of the M50 metallopeptidase family include: mammalian sterol-regulatory element binding protein (SREBP) site 2 protease and Escherichia coli protease EcfE, stage IV sporulation protein FB.
[2] Overall, all MMPs are inhibited by TIMPs once they are activated, but the gelatinases ( MMP-2 and MMP-9 ) can form complexes with TIMPs when the enzymes are in their latent form. The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP ( MMP-14 ), a membrane-anchored MMP.
5-(spiropyrrolidin-5-yl)pyrimidinetrione is a compound named 848773-43-3 that is a potent MMP-2, MMP-9 and MMP-13 inhibitor that spares MMP-1 and TACE. By substituting 1,3,4-oxadiazol-2-yl heteroaryl at C-4’ of the diphenylether segment to accomplish MMP-13 selectivity over MT-1 MMP, made the compound 420121-84-2.
7077 21858 Ensembl ENSG00000035862 ENSMUSG00000017466 UniProt P16035 P25785 RefSeq (mRNA) NM_003255 NM_011594 RefSeq (protein) NP_003246 n/a Location (UCSC) Chr 17: 78.85 – 78.93 Mb Chr 11: 118.19 – 118.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene ...
The human MMP-20 gene contains 10 exons and is part of a cluster of matrix metalloproteinase genes that localize to human chromosome 11q22.3. [6] A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta .