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72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. [5] The MMP2 gene is located on chromosome 16 at position 12.2.
The active site is a 20 Å (2 nm) groove that runs across the catalytic domain. In the part of the catalytic domain forming the active site there is a catalytically important Zn 2+ ion, which is bound by three histidine residues found in the conserved sequence HExxHxxGxxH. Hence, this sequence is a zinc-binding motif.
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria. [ 5 ] Members of the M50 metallopeptidase family include: mammalian sterol-regulatory element binding protein (SREBP) site 2 protease and Escherichia coli protease EcfE, stage IV sporulation protein FB.
4324 17388 Ensembl ENSG00000102996 ENSMUSG00000031790 UniProt P51511 O54732 RefSeq (mRNA) NM_002428 NM_008609 RefSeq (protein) NP_002419 NP_032635 Location (UCSC) Chr 16: 58.03 – 58.05 Mb Chr 8: 96.08 – 96.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metalloproteinase 15 also known as MMP15 is an enzyme that in humans is encoded by the MMP15 gene. Function Proteins of ...
The human MMP-20 gene contains 10 exons and is part of a cluster of matrix metalloproteinase genes that localize to human chromosome 11q22.3. [6] A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta .
7077 21858 Ensembl ENSG00000035862 ENSMUSG00000017466 UniProt P16035 P25785 RefSeq (mRNA) NM_003255 NM_011594 RefSeq (protein) NP_003246 n/a Location (UCSC) Chr 17: 78.85 – 78.93 Mb Chr 11: 118.19 – 118.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene ...
Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene. [5] [6]Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
N 2 + 16 MgATP + 8 e − → 2 NH 3 + 16 MgADP +16 P i + H 2. where P i stands for inorganic phosphate. The precise structure of the active site has been difficult to determine. It appears to contain a MoFe 7 S 8 cluster that is able to bind the dinitrogen molecule and, presumably, enable the reduction process to begin. [31]