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A new therapy for metastatic melanoma was shown to be more effective than a leading immunotherapy for the skin cancer. Skip to main content. 24/7 Help. For premium support please call: 800-290 ...
Lifileucel, sold under the brand name Amtagvi, is an adoptive T cell therapy used for the treatment of melanoma. [1] [2] [3] Specifically, lifileucel is a tumor-derived T cell immunotherapy composed of a recipient's own T cells. A portion of the recipient's tumor tissue is removed during a surgical procedure prior to treatment. [3]
On February 1, 2012, Health Canada approved ipilimumab for "treatment of unresectable or metastatic melanoma in patients who have failed or do not tolerate other systemic therapy for advanced disease." [24] Ipilimumab was approved in the European Union (EU), for second line treatment of metastatic melanoma in November 2012. [25] [26]
Talimogene laherparepvec is delivered by injecting it directly into tumors, thereby creating a systemic anti-tumor immune response. [2]In the US, talimogene laherparepvec is FDA approved to treat Stage IIIb-IVM1c melanoma patients for whom surgical intervention is not appropriate and with tumors which can be directly injected; the EMA approved population in Europe is for Stage IIIb-IVM1a.
IL-2 was the first new therapy approved (1990 EU, 1992 US) for the treatment of metastatic melanoma in 20 years. [139] IL-2 may offer the possibility of a complete and long-lasting remission in this disease in a small percentage of people with melanoma. [ 140 ]
In early 2010 a Phase I trial [16] for solid tumors (including colorectal cancer), and a phase II study (for metastatic melanoma) were ongoing. [17] A phase III trial (vs dacarbazine) in patients with previously untreated metastatic melanoma showed an improved rates of overall and progression-free survival. [18]
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