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Meta-analysis is a method of synthesis of quantitative data from multiple independent studies addressing a common research question. An important part of this method involves computing a combined effect size across all of the studies.
In medical research, an umbrella review is a review of systematic reviews or meta-analyses. [1] [2] [3] They may also be called overviews of reviews, reviews of reviews, summaries of systematic reviews, or syntheses of reviews. [1] Umbrella reviews are among the highest levels of evidence currently available in medicine. [2]
A meta-analysis is a statistical analysis that combines the results of multiple quantitative studies. Using statistical methods, results are combined to provide evidence from multiple studies. The two types of data generally used for meta-analysis in health research are individual participant data and aggregate data (such as odds ratios or ...
A meta-regression can be classified in the same way—meta-regression and network meta-regression—depending on the number of distinct treatments in the regression analysis. Meta-analysis (and meta-regression) is often placed at the top of the evidence hierarchy provided that the analysis consists of individual participant data of randomized ...
Meta-research has identified poor practices in reporting, explaining, disseminating and popularizing research, particularly within the social and health sciences. Poor reporting makes it difficult to accurately interpret the results of scientific studies, to replicate studies, and to identify biases and conflicts of interest in the authors.
Meta-analysis is a method used to combine the results of different trials in order to obtain a quantitative synthesis. The size of individual clinical trials is often too small to detect treatment effects reliably. Meta-analysis increases the power of statistical analyses by pooling the results of all available trials.
A meta-analysis lends itself more to statistical research, often converting the original research into one common metric referred to as "effect sizes", so as to easily identify patterns and anomalies among publications. Systematic reviews may include meta-analysis results. [6]
In an IPD meta-analysis, patient-level data from multiple studies or settings are combined to address a certain research question. IPD meta-analyses tend to be common for large-scale and international projects, and they are less limited than aggregate data (AD) meta-analyses in terms of the availability and quality of data they can use. [2]