Search results
Results From The WOW.Com Content Network
The Kell antigen system (also known as the Kell–Cellano system) is a human blood group system, that is, a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. The Kell antigens are K, k, Kp a, Kp b, Js a and Js ...
Mothers who are negative for the Kell 1 antigen develop antibodies after being exposed to red blood cells that are positive for Kell 1.Over half of the cases of hemolytic disease of the newborn owing the anti-Kell antibodies are caused by multiple blood transfusions, with the remainder due to a previous pregnancy with a Kell 1 positive baby.
Blood group antigens besides ABO and RhD that are significant in transfusion medicine include the RhC/c and E/e antigens and the antigens of the Duffy, Kell, Kidd, and MNS systems. [ 1 ] : 158–173 If a clinically significant antibody is identified, the recipient must be transfused with blood that is negative for the corresponding antigen to ...
Anti-Kell hemolytic disease of the newborn is most commonly caused by anti-K 1 antibodies, the second most common form of severe HDN. Over half of the cases of anti-K 1 related HDN are caused by multiple blood transfusions. Antibodies to the other Kell antigens are rare. [19] Anti-Kell can cause severe anemia regardless of titer. [22]
Once antigen status has been determined, assessment may be done with MCA scans. [citation needed] Cell-free DNA can be run on certain antigens. Blood is taken from the mother, and using PCR, can detect the K, C, c, D, and E alleles of fetal DNA. This blood test is non-invasive to the fetus and is an easy way of checking antigen status and risk ...
McLeod syndrome was discovered in 1961 and, similar to the Kell antigen system, was named after the first patient in which it was discovered; a dental student by the name of Hugh McLeod. McLeod's red blood cells demonstrated a peculiar appearance when viewed microscopically ( acanthocytic (spiky)) and showed weak expression of Kell system antigens.
Once antigen status has been determined, assessment may be done with MCA scans. [citation needed] Cell-free DNA can be run on certain antigens. Blood is taken from the mother, and using PCR, can detect the K, C, c, D, and E alleles of fetal DNA. This blood test is non-invasive to the fetus and is an easy way of checking antigen status and risk ...
The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...