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The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug ...
Gradient responsive drug delivery systems are stimulated to deliver therapeutics through contact with an endogenous chemical gradient. When the system comes into contact with its specific chemical gradient, increased concentration of the chemical can lead to the conformational change or degradation of a drug carrier to allow drug release.
The physical properties of hydrogels can be adjusted to meet specific requirements for various drug delivery systems. pH-responsive hydrogels have been extensively developed recently and have proven particularly useful for targeted cancer treatment. They can prolong drug release and are quick and cost-effective to synthesize. [12]
Targeted drug delivery is the delivery of a drug to its target site without having an effect on other tissues. [22] Interest in targeted drug delivery has grown drastically due to its potential implications in the treatment of cancers and other chronic diseases.
Biomarkers are usually required to aid the selection of patients who will likely respond to a given targeted therapy. [7] Co-targeted therapy involves the use of one or more therapeutics aimed at multiple targets, for example PI3K and MEK, in an attempt to generate a synergistic response [6] and prevent the development of drug resistance. [8] [9]
In this drug delivery system, after the drug reaches the target site and tumor cell uptake is complete, an external magnetic field is applied causing a magnetothermal effect, raising the tumor cells' temperature and further promoting drug uptake. This nanocarrier system aims to improve drug stability, control drug release, and improve tumor ...
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
With an increase in respiratory disease cases, the need for a drug delivery system that can be targeted to the lungs and provide sustained release is becoming more severe. This type of system would be applicable to patients experiencing asthma, pneumonia, obstructive pulmonary disease, and a number of other lung related diseases. [4]