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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
Moreover, CTCF and cohesin play important roles in determining TADs and enhancer-promoter interactions. The result shows that the orientation of CTCF binding motifs in an enhancer-promoter loop should be facing to each other in order for the enhancer to find its correct target.
CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a ...
From its first version Excel supported end-user programming of macros (automation of repetitive tasks) and user-defined functions (extension of Excel's built-in function library). In early versions of Excel, these programs were written in a macro language whose statements had formula syntax and resided in the cells of special-purpose macro ...
In Microsoft Excel, these functions are defined using Visual Basic for Applications in the supplied Visual Basic editor, and such functions are automatically accessible on the worksheet. Also, programs can be written that pull information from the worksheet, perform some calculations, and report the results back to the worksheet.
Power Pivot, formerly known as PowerPivot (without spacing), is a self-service business intelligence feature of Microsoft Excel which facilitates the creation of a tabular model to import, relate, and analyze data from a variety of sources.