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Hypophosphatasia (/ ˌ h aɪ p oʊ ˈ f ɒ s f eɪ t ˌ eɪ ʒ ə /; also called deficiency of alkaline phosphatase, phosphoethanolaminuria, [5] or Rathbun's syndrome; [1] sometimes abbreviated HPP [6]) is a rare, and sometimes fatal, inherited [7] metabolic bone disease. [8]
Mutations in the ALPL gene lead to varying low activity of the enzyme tissue-nonspecific alkaline phosphatase (TNSALP or TNAP) resulting in hypophosphatasia (HPP). [21] There are different clinical forms of HPP which can be inherited by an autosomal recessive trait or autosomal dominant trait, [ 18 ] the former causing more severe forms of the ...
Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. [1] Symptoms may include weakness, trouble breathing, and loss of appetite. [1]
Canada's public health authority says around one million KN95 respirators acquired from China have failed to meet federal Covid-19 standards for use by frontline health professionals.
The COVID-19 pandemic in New Brunswick is an ongoing viral pandemic of coronavirus disease 2019 , a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 . The province of New Brunswick has the eight-most cases (out of ten provinces and three territories) of COVID-19 in Canada , having confirmed their first case on ...
Hypophosphatasia is caused by a genetic defect of tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme that plays a role in bone mineralization. Asfotase alfa is a recombinant glycoprotein that contains the catalytic domain (the active site) of TNSALP. It is thus a form of enzyme replacement therapy. [5] [12]
The COVID-19 pandemic in Newfoundland and Labrador is an ongoing viral pandemic of coronavirus disease 2019 , a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of April 12, 2023, there have been 55,091 cases and 339 deaths confirmed in Newfoundland and Labrador. As of April 13, 2023, 745,617 ...
The COVID-19 pandemic in Canada is part of the ongoing worldwide pandemic of coronavirus disease 2019 . It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Most cases over the course of the pandemic have been in Ontario, Quebec, British Columbia and Alberta. Confirmed cases have been reported in all of Canada's ...