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The hippocampal formation is a compound structure in the medial temporal lobe of the brain. It forms a c-shaped bulge on the floor of the inferior horn of the lateral ventricle . [ 1 ] Typically, the hippocampal formation is said to included the dentate gyrus , the hippocampus , and the subiculum . [ 2 ]
Hippocampus in the human brain Nissl-stained coronal section of the brain of a macaque monkey, showing hippocampus (circled). Hippocampus anatomy describes the physical aspects and properties of the hippocampus, a neural structure in the medial temporal lobe of each cerebral hemisphere of the brain.
The hippocampus (pl.: hippocampi; via Latin from Greek ἱππόκαμπος, 'seahorse'), also hippocampus proper, is a major component of the brain of humans and many other vertebrates. In the human brain the hippocampus, the dentate gyrus, and the subiculum are the components of the hippocampal formation located in the limbic system.
The hippocampal subfields are four subfields CA1, CA2, CA3, and CA4 that make up the structure of the hippocampus. Regions described in the hippocampus are the head, body, and tail, and other hippocampal subfields include the dentate gyrus , the presubiculum , and the subiculum .
The dentate gyrus (DG) is one of the subfields of the hippocampus, in the hippocampal formation. The hippocampal formation is located in the temporal lobe of the brain, and includes the hippocampus (including CA1 to CA4) subfields, and other subfields including the dentate gyrus, subiculum, and presubiculum. [1] [2]
View of left entorhinal cortex (red) from beneath the brain, with front of brain at top. Artist's rendering. The superficial layers – layers II and III – of EC project to the dentate gyrus and hippocampus: Layer II projects primarily to dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 and the subiculum.
The hippocampal formation, which consists of the hippocampus, perirhinal cortex, the dentate gyrus, the subicular areas and the EC forms one of the most important parts of the limbic system. The entorhinal cortex is an infolding of the parahippocampal gyrus into the inferior (temporal) horn of the lateral ventricle .
The trisynaptic circuit is a neural circuit in the hippocampus, which is made up of three major cell groups: granule cells in the dentate gyrus, pyramidal neurons in CA3, and pyramidal neurons in CA1. The hippocampal relay involves three main regions within the hippocampus which are classified according to their cell type and projection fibers.