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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
H&E stain. Prussian blue iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or portal macrophages) rather than parenchymal iron overload (within hepatocytes). [7] There are several methods available for diagnosing and monitoring hemosiderosis including: Serum ...
The H&E staining procedure is the principal stain in histology [3] [7] [2] [5] in part because it can be done quickly, [7] is not expensive, and stains tissues in such a way that a considerable amount of microscopic anatomy [9] [10] is revealed, [7] [5] [4] and can be used to diagnose a wide range of histopathologic conditions. [8]
Gastritis is the inflammation of the lining of the stomach. [1] It may occur as a short episode or may be of a long duration. [1] There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia). [1]
Women’s bodies go through many changes in menopause and the years leading up to it, known as perimenopause. This natural step in the aging process marks the end of the reproductive years. In ...
Women are about twice as often diagnosed with gastric antral vascular ectasia than men. [2] [7] 71% of all cases of GAVE are diagnosed in females. [3] [7] Patients in their thirties have been found to have GAVE. [6] It becomes more common in women in their eighties, rising to 4% of all such gastrointestinal conditions. [10]
H&E stain. Common cancer types that are associated with hypercalcemia of malignancy include: Solid tumor with metastasis via local osteolytic hypercalcemia: which can be due to any tumor that metastasizes to the bone. But common causes include breast cancer, lung cancer, kidney cancer, and myeloma or lymphoma of the bone [22]
Radiation and some chemotherapy, however, increase the risk of other cancers, heart disease, or nerve problems over the subsequent decades. [1] In 2015, about 4.3 million people had non-Hodgkin lymphoma, and 231,400 (5.4%) died. [4] [5] In the United States, 2.1% of people are affected at some point in their life. [2]