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This article needs to be updated. The reason given is: Many outdated sources and information (older than five years). Please help update this article to reflect recent events or newly available information. (July 2024) Medical condition Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Specialty Psychiatry ...
Major depression is often associated with biomarkers indicative of inflammatory responses, with interleukin-6, interleukin-1, interleukin-2 receptor, tumor necrosis factor alpha, C-reactive protein, and monocyte chemotactic protein-1 all being found to be elevated in those with depression. [2] [8] [1] [5] [3] Similarly, the same biomarkers are ...
Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death. It is the result of inhibited or suppressed brain activity .
[23] [24] For instance, studies have also shown a relationship between depression and its cognitive effects on everyday functioning and distortions of memory. [ 25 ] Since pseudodementia does not cause deterioration of the brain, brain scans can be used to visualize potential deterioration associated with dementia.
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD). [1]
It is speculated to have a role in depression, as some depressed patients have been reported to exhibit lower concentrations of metabolites of serotonin in their cerebrospinal fluid and brain tissue. [30] Norepinephrine is a member of the catecholamine family of neurotransmitters. It is synthesized from the amino acid tyrosine.
In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.
Negative affect is the factor that is common to both anxiety and depression. Negative affect can be defined as, "the extent to which an individual feels upset or unpleasantly engaged, rather than peaceful". [1] It involves negative mood states such as subjective distress, fear, disgust, scorn, and hostility. [9]
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