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In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates. It is caused by the surface of the red cells being coated with antibodies .
This image explains agglutination in the blood. Agglutination is the clumping of particles. The word agglutination comes from the Latin agglutinare (glueing to).. Agglutination is a reaction in which particles (as red blood cells or bacteria) suspended in a liquid collect into clumps usually as a response to a specific antibody.
Rouleaux formation on wet smear. Rouleaux (singular is rouleau) are stacks or aggregations of red blood cells (RBCs) that form because of the unique discoid shape of the cells in vertebrates.
The direct and indirect Coombs tests, also known as antiglobulin test (AGT), are blood tests used in immunohematology.The direct Coombs test detects antibodies that are stuck to the surface of the red blood cells. [1]
A slide coagulase test is run with a negative control to rule out autoagglutination. Two drops of saline are put onto the slide labeled with sample number, Test (T) and control (C). The two saline drops are emulsified with the test organism using a wire loop, straight wire, or wooden stick.
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Svante Arrhenius was also one of the pioneers in the field; he published Immunochemistry in 1907 which described the application of the methods of physical chemistry to the study of the theory of toxins and antitoxins.
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