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Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome. The transcriptome of p63 mutant keratinocytes deviated from the normal epidermal cell identity. [24] Vitamin A and its analogues. [25] Epidermal growth factor. [26] Transforming growth factor alpha. [27] Cholera ...
The epidermis primarily consists of keratinocytes [4] (proliferating basal and differentiated suprabasal), which comprise 90% of its cells, but also contains melanocytes, Langerhans cells, Merkel cells, [6]: 2–3 and inflammatory cells. Epidermal thickenings called Rete ridges (or rete pegs) extend downward between dermal papillae. [7]
The human skin is the outer covering of the body and is the largest organ of the integumentary ... Epidermal Keratinocytes 1.1E+11 85.5 10.1% Hair Follicle 1.3E+11 ...
Epidermidibacterium keratini is a Gram-positive, chemoheterotrophic, non-motile, non-sporeforming, rod-shaped, aerobic bacterium that it was first isolated from human epidermal keratinocytes in 2018. [1] It is part of the normal human flora, typically the skin flora. [2]
A deficiency is associated with ichthyosis lamellaris. [11] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.. A study on the mutation of keratinocyte transglutaminase (TGK) came to conclude that those affected with ichthyosis lamellaris, present a substantial deficit in keratinocyte transglutaminase activity. [8]
HaCaT is a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin, [1] [2] widely used in scientific research. [3] HaCaT cells are utilized for their high capacity to differentiate and proliferate in vitro. [4]
This ultimately results in functional squamous cells on the outermost layer of the epidermis, the most abundant of which are called keratinocytes. The continuous division of epidermal basal cells leads to complete epidermal turnover every 40-56 days in humans and every 8-10 days in mice. [7]
Keratohyalin is a protein structure found in cytoplasmic granules of the keratinocytes in the stratum granulosum of the epidermis.Keratohyalin granules (KHG) mainly consist of keratin, profilaggrin, [1] loricrin [2] and trichohyalin proteins which contribute to cornification or keratinization, the process of the formation of epidermal cornified cell envelope.