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The therapeutic recommended dosages were 12.5, 25, and 50 mg with an approximate bioavailability of 93%. [12] [13] [14] Rofecoxib crossed the placenta and blood–brain barrier, [12] [13] [15] and took 1–3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) around 17 hours.
Voluntarily withdrawn from US market because of risk of Progressive multifocal leukoencephalopathy (PML). Returned to market July 2006. Nefazodone: 2004 Europe, Australia, New Zealand and Canada [35] [36] [37] Branded version withdrawn by originator in several countries in 2007 for hepatotoxicity. Generic versions available. Still available in ...
Sales and marketing efforts were supported by two large trials, the Celecoxib Long-term Arthritis Safety Study [44] (CLASS) in JAMA, and the Vioxx Gastrointestinal Outcomes Research (VIGOR). [45] The VIGOR trial was later proven to have been based on faulty data, and Vioxx was eventually withdrawn from the market. [46]
SHANGHAI (Reuters) - As Novo Nordisk and Eli Lilly expand sales of their popular diabetes and weight-loss drugs, cheaper copies of their patented remedies are winning approval from some regulators ...
In 2006, while completing his doctorate at Harvard, Feigl-Ding co-authored a study on COX-2 inhibitors that confirmed serious risks specifically associated with the drug, Vioxx, which Merck had withdrawn from the market two years earlier, in 2004, and which argued that Merck should have known about the risks.
Osiel Cárdenas Guillén, a notorious Mexican drug lord, was removed from the U.S. and handed over to authorities in Mexico, ICE said on Monday. ICE removes notorious drug cartel leader from US ...
Eli Lilly & Co., the Fortune 500 pharma firm that manufactures weight-loss injection Zepbound (tirzepatide), has a comparable oral medication in the works that could be approved by the FDA as ...
APCO handled the crisis for Merck & Co's withdrawal of Vioxx from the market. [12] Kazakhstan's president, Nursultan Nazarbayev hired APCO to extricate himself from a four-year-long dispute with his former son-in-law Rakhat Aliyev.