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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck ( IC 50 =4 nM ), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM).
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They settled on nile red, a compound for dyeing used in biochemistry, as it sounded good and did not sound much like a chemical. A second channel, NileBlue, was created in 2016 to showcase more casual projects than the main channel, and a shorts channel, NileRed 2 (formerly NileRed Shorts), was created in 2021.
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