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Chloral hydrate is a geminal diol with the formula Cl 3 C−CH(OH) 2. It was first used as a sedative and hypnotic in Germany in the 1870s. Over time it was replaced by safer and more effective alternatives but it remained in usage in the United States until at least the 1970s. [ 4 ]
In slang, a Mickey Finn, or simply a Mickey (often called a spiked drink), is a drink laced with an incapacitating agent, particularly chloral hydrate, given to someone without their consent with the intent to incapacitate them or "knock them out"; hence the colloquial name knockout drops.
In 1832 produced chloral hydrate, the first synthetic sleeping drug. In 1833 French chemist Anselme Payen was the first to discover an enzyme, diastase. In 1834, François Mothes and Joseph Dublanc created a method to produce a single-piece gelatin capsule that was sealed with a drop of gelatin solution.
Chloral tends to form adducts with water (to give chloral hydrate) and alcohols. Aside from its tendency to hydrate, chloral is notable as a building block in the synthesis of DDT. For this purpose, chloral is treated with chlorobenzene in the presence of a catalytic amount of sulfuric acid: Cl 3 CCHO + 2 C 6 H 5 Cl → Cl 3 CCH(C 6 H 4 Cl) 2 ...
Carr also requested a doctor for Williams, as he was feeling the combination of the chloral hydrate and alcohol he had drunk on the way from Montgomery to Knoxville. [9] Dr. P.H. Cardwell injected Williams with two shots of vitamin B12 that also contained a quarter-grain (16.2 mg) of morphine.
He is well known for his investigations pertaining to the sedative and hypnotic properties of chloral hydrate (1869), and was an important factor in the drugs' popularity during the latter half of the 19th century.
A history of long-term exposure to high concentrations of trichloroethylene is a suspected ... Chloral hydrate is either reduced to 2,2,2-trichloroethanol or oxidised ...
Dichloralphenazone is a 1:2 mixture of antipyrine with chloral hydrate. In combination with paracetamol and isometheptene, it is the active ingredient of medications for migraine and tension headaches, including Epidrin and Midrin. Performance impairments are common with this drug and caution is advised, for example when driving motor vehicles.