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  2. Beta blocker - Wikipedia

    en.wikipedia.org/wiki/Beta_blocker

    Beta blockers vary in their lipophilicity (fat solubility) and in turn in their ability to cross the blood–brain barrier and exert effects in the central nervous system. [76] Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects ...

  3. Phentolamine - Wikipedia

    en.wikipedia.org/wiki/Phentolamine

    The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma. [5]It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers (e.g. metoprolol), as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and ...

  4. Levamisole induced necrosis syndrome - Wikipedia

    en.wikipedia.org/wiki/Levamisole_Induced...

    Levamisole has become a common additive to illicit cocaine. It is thought to intensify the "high" by releasing dopamine in the brain, acts as a bulking agent, and is a difficult adulterant to recognize. Potential risks of levamisole-laced cocaine include neutropenia, agranulocytosis, arthralgias, retiform purpura, skin necrosis, and fever.

  5. Discovery and development of beta-blockers - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The β-blockers are an immensely important class of drugs due to their high prevalence of use. The discovery of β-blockers reaches back to more than 100 years ago, when early investigators came up with the idea that catecholamines were binding selectively to receptor-like structures and that this was the cause of their pharmacological actions. [3]

  6. Adrenergic storm - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_storm

    diazepam, benzodiazepines, beta blockers, anti-hypertensives An adrenergic storm is a sudden and dramatic increase in serum levels of the catecholamines adrenaline and noradrenaline (also known as epinephrine and norepinephrine respectively), with a less significant increase in dopamine transmission.

  7. Antibiotic use does not increase dementia risk, study suggests

    www.aol.com/lifestyle/antibiotic-does-not...

    During the 5-year follow-up, 461 people developed dementia, and 2,576 people developed cognitive impairment. After adjusting for sociodemographic and lifestyle factors, family history of dementia ...

  8. Diazepam - Wikipedia

    en.wikipedia.org/wiki/Diazepam

    Diazepam does not possess any chiral centers in its structure, but it does have two conformers.The two conformers mentioned were the 'P'-conformer and 'M'-conformer. Diazepam is an equimolar mixture and it was shown through CD spectra in serum protein solutions, that the 'P'-conformer is preferred by α1-acid glycoprotein b

  9. These before and after photos show the real effects of heroin use

    www.aol.com/news/2016-05-01-these-before-and...

    The heroin and opioid abuse epidemic is hitting America hard with heroin use more than doubling in the past decade among young adults, according to the CDC.While the dire statistics tell the ...