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Post-stroke depression (PSD) is a form of depression that may occur after a stroke. PSD significantly impacts stroke recovery and the overall quality of life of those affected. It is particularly associated with strokes affecting the basal ganglia or the anterior regions of the brain, including the hippocampus and prefrontal cortex.
The number of people with depression has reached new highs—and so has antidepressant use. As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight ...
[11] [59] [72] The two common sexual side effects are diminished interest in sex (libido) and difficulty reaching climax , which are usually somewhat milder with SNRIs compared to SSRIs. [73] To manage sexual dysfunction, studies have shown that switching to or augmenting with bupropion or adding a PDE5 Inhibitor have decreased symptoms of ...
Further, they have fewer and milder side effects. Tricyclic antidepressants also have a higher risk of serious cardiovascular side effects, which SSRIs lack. SSRIs act on signal pathways such as cyclic adenosine monophosphate (cAMP) on the postsynaptic neuronal cell, which leads to the release of brain-derived neurotrophic factor (BDNF). BDNF ...
Sexual side effects. Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as ...
Traditionally, tricyclic antidepressants (TCAs), such as nortriptyline, have been used in the treatment of post-stroke depression. More recently, the selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine and citalopram , have become the pharmacologic therapy of choice due to the lower incidence of side effects .
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