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Angiotensin II causes the muscular walls of small arteries (arterioles) to constrict (narrow), increasing blood pressure. Angiotensin II also triggers your adrenal glands to release aldosterone and your pituitary gland to release antidiuretic hormone (ADH, or vasopressin).
Objectives: Identify the indications approved for II in the therapeutic setting. Review the dose forms and dosing parameters for angiotensin II. Summarize monitoring, contraindications, and toxicity for angiotensin II.
Angiotensin II acts on the central nervous system to increase vasopressin production, and also acts on venous and arterial smooth muscle to cause vasoconstriction. Angiotensin II also increases aldosterone secretion; it therefore acts as an endocrine, autocrine / paracrine, and intracrine hormone.
ACE generates angiotensin II by cleaving the two amino acids at the C-terminal of angiotensin I. Angiotensin II is the primary mediator of the physiologic effects of RAAS, including blood pressure, volume regulation, and aldosterone secretion.
Angiotensin II (Ang II) raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions.
Angiotensin II causes the muscular walls of small arteries (arterioles) to constrict (narrow), which increases blood pressure. Angiotensin II also triggers your adrenal glands to release aldosterone and your pituitary gland to release antidiuretic hormone (ADH, or vasopressin).
Angiotensin II is a very powerful hormone that can act directly on blood vessels, causing them to become narrow, or constrict, to increase blood pressure. It has another important function as well—stimulating the release of aldosterone.
Angiotensin II serves at least three important functions in the kidney: autoregulation of GFR, reduction of salt excretion through direct and indirect actions on renal tubular cells, and growth modulation of renal cells expressing AT 1 receptors.
Angiotensin 2 receptor blockers stop the action of angiotensin 2. As a result, the medicine helps relax the veins and arteries in the body, lowering blood pressure. Several angiotensin 2 receptor blockers are available.
Angiotensin II acts at several levels to ensure the regulation of cardiovascular and renal function and body homeostasis. Renin (R) is an acid protease synthesised and stored by secretory vesicles in the juxtaglomerular cells of the dense renal macula.