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In medicine, the urea-to-creatinine ratio (UCR [1]), known in the United States as BUN-to-creatinine ratio, is the ratio of the blood levels of urea (mmol/L) and creatinine (Cr) (μmol/L). BUN only reflects the nitrogen content of urea (MW 28) and urea measurement reflects the whole of the molecule (MW 60), urea is just over twice BUN (60/28 ...
Normally we measure postdialysis serum urea nitrogen concentration C and compare this with the initial or predialysis level C 0. The session length or time is t and this is measured by the clock. The dialyzer clearance K is usually estimated, based on the urea transfer ability of the dialyzer (a function of its size and membrane permeability ...
Measurements of urea and creatinine (Cr) in the blood are used to assess renal function. For historical reasons, the lab test measuring urea is known as "blood urea nitrogen" (BUN) in the US. The BUN:Cr ratio is a useful measure in determining the type of azotemia and will be discussed in each section below. A normal BUN:Cr is equal to 15. [3]
A simple means of estimating renal function is to measure pH, blood urea nitrogen, creatinine, and basic electrolytes (including sodium, potassium, chloride, and bicarbonate). As the kidney is the most important organ in controlling these values, any derangement in these values could suggest renal impairment.
Along with UUN, values for BUN, protein content of diet, enteral or parenteral nutrition, and notable outputs other than urine (gastric residual, fistula output, drainages) are needed to calculate nitrogen balance. Nitrogen Balance = Protein intake/6.25- (UN + 4*) * For average loss via sweat and feces.
The URR is designed to measure the amount of dialysis given when the dialysis clearance of urea greatly exceeds the urea generation rate. In continuous hemodialysis or in peritoneal dialysis , for example, a considerable amount of dialysis is delivered, but the urea level remains roughly constant after the initial treatment of uremia, so the ...
BUN – blood urea nitrogen: 7 [14] 18, [14] 21 [15] mg/dL * Uric acid [15] 0.18 [14] 0.48 [14 ... May be complemented with creatinine clearance: 0.7, [175] 0.8 [175 ...
The above formula only applies for GFR calculation when it is equal to the clearance rate. The normal range of GFR, adjusted for body surface area , is 100–130 average 125 (mL/min)/(1.73 m 2 ) in men and 90–120 (mL/min)/(1.73 m 2 ) in women younger than the age of 40.