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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Other causes can include acid reflux, asthma, allergies, or other chronic medical conditions, adds Richard Watkins, M.D., an infectious disease physician and professor of medicine at the Northeast ...
Mucoactive drugs include expectorants, mucolytics, mucoregulators, and mucokinetics. These medications are used in the treatment of respiratory diseases that are complicated by the oversecretion or inspissation of mucus. These drugs can be further categorized by their mechanism of action. [1] [2]
Nonsteroidal anti-inflammatory drugs (NSAIDs) [4] can cause increased gastric acid secretion, diminished bicarbonate secretion, diminished mucus secretion and diminished trophic effects on epithelial mucosa by inhibiting COX-1, COX-2 and prostaglandins.
The classification organizes the hypersensitivity reactions to NSAIDs into the following five categories: NSAIDs-exacerbated respiratory disease (NERD) is an acute (immediate to several hours) exacerbation of bronchoconstriction and other symptoms of asthma in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of rhinitis and sinusitis in individuals ...
A lot of different things can cause a cough. But coughs are usually broken down into two main categories: acute and chronic. Acute coughs are ones that come on suddenly, usually due to an illness.
In fact, Dr. Shawn Nasseri, MD, ENT-otolaryngologist based in Los Angeles and co-founder of Euka, notes that during seasonal allergies, foods may be consumed that can cause inflammation in the ...
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), particularly those that inhibit cyclooxygenase 1 , can worsen rhinitis and asthma symptoms in individuals with a history of either one of these diseases. [32] These exacerbations most often appear due to NSAID hypersensitivity reactions rather than NSAID-induced allergic reactions.