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Due to its ability to induce cell cycle arrest, ionizing radiation is used on abnormal growths in the human body such as cancer cells, in radiation therapy. Most cancer cells are fully treated with some type of radiotherapy, however some cells such as stem cell cancer cells show a reoccurrence when treated by this type of therapy. [1]
Radiation damage is the effect of ionizing radiation on physical objects including non-living structural materials. It can be either detrimental or beneficial for materials. It can be either detrimental or beneficial for materials.
Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation in a short period of time. [1] Symptoms can start within an hour of exposure, and can last for several months.
The best known explanation of the oxygen effect is the oxygen fixation hypothesis developed by Alexander in 1962, [9] which posited that radiation-induced non-restorable or "fixed" nuclear DNA lesions are lethal to cells in the presence of diatomic oxygen. [10] [11] Recent hypotheses include one based on oxygen-enhanced damage from first ...
When dried and frozen, Deinococcus radiodurans could survive 140,000 grays, or units of X-and gamma-ray radiation, which is 28,000 times greater than the amount of radiation that could kill a person.
Cells have developed complex and efficient repair mechanisms to fix the lesions. In the case of free radical attack on DNA, base-excision repair is the repair mechanism used. Hydroxyl radical reactions with the deoxyribose sugar backbone are initiated by hydrogen abstraction from a deoxyribose carbon, and the predominant consequence is eventual ...
Bone marrow death is caused by a dose of radiation between 2 and 10 Gray and is characterized by the part of the bone marrow that makes the blood being broken down. Therefore, production of red and white blood cells and platelets is stopped due to loss of the blood-making stem cells (4.5 Gray kills 95% of stem cells).
The least sensitive are nerve cells and muscle fibers. Very sensitive cells are also oocytes and lymphocytes, although they are resting cells and do not meet the criteria described above. The reasons for their sensitivity are not clear. There also appears to be a genetic basis for the varied vulnerability of cells to ionizing radiation. [4]