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Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
For medications, the term immunosuppression generally refers to both beneficial and potential adverse effects of decreasing the function of the immune system, while the term immunodeficiency generally refers solely to the adverse effect of increased risk for infection. Many specific diseases directly or indirectly cause immunosuppression.
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. [5] There are at least 80 types of autoimmune diseases. [5] Nearly any body part can be involved. Common symptoms include low-grade fever and feeling tired. [5] Often symptoms come and go. [5]
Various other autoimmune diseases or hypersensitivity are common in other individuals with IPEX syndrome. [2] In addition to autoimmune diseases, individuals experience higher immune reactivity (e.g. chronic dermatitis) and susceptibility to infections. Individuals also develop autoimmune diseases at a young age. [4]
Cyclophosphamide (Baxter's Cytoxan) is probably the most potent immunosuppressive compound. In small doses, it is very efficient in the therapy of systemic lupus erythematosus, autoimmune hemolytic anemias, granulomatosis with polyangiitis, and other immune diseases. High doses cause pancytopenia and hemorrhagic cystitis.
It is more often that hypogammaglobulinemia develops as a result of another condition, which are called secondary or acquired immune deficiencies. These include blood cancers such as chronic lymphocytic leukemia (CLL), lymphoma , or myeloma , HIV , nephrotic syndrome , poor nutrition, protein-losing enteropathy , getting an organ transplant ...
This condition can also be caused by or occur with another disorder (secondary) or rarely, occur following the use of certain drugs (such as penicillin) or after a person has a blood and marrow stem cell transplant. [14] Secondary causes of autoimmune hemolytic anemia include: [14] Autoimmune diseases, such as lupus; Chronic lymphocytic leukemia