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Immunosuppressive drugs, also known as immunosuppressive agents, ... Prolonged use of opioids may cause immunosuppression of both innate and adaptive immunity. [9]
Immunosuppressive drugs have the potential to cause immunodeficiency, which can increase susceptibility to opportunistic infection and decrease cancer immunosurveillance. [9] Immunosuppressants may be prescribed when a normal immune response is undesirable, such as in autoimmune diseases .
SAAM is treated by stopping the offending statin medication and taking immunosuppressive medications. [7] In rare cases, affected people spontaneously improve after just stopping the implicated statin. [3] However, most cases mandate the use of immunosuppressive medication. [8] Corticosteroids are considered first-line treatment.
The explanation for this is that while "biologic" or "biopharmaceutical" refers to the chemical composition of medications which might be used to treat a range of medical conditions, when the term "biologic" became popular, many biologic medications available provided immunosuppression. [25]
For medications, the term immunosuppression generally refers to both beneficial and potential adverse effects of decreasing the function of the immune system, while the term immunodeficiency generally refers solely to the adverse effect of increased risk for infection. Many specific diseases directly or indirectly cause immunosuppression.
The suppression of CD4 T cells by HIV (or by immunosuppressive drugs) causes a decrease in the body's normal response to certain infections. Not only does this make it more difficult to fight the infection, it may mean that a level of infection that would normally produce symptoms is instead undetected (subclinical infection).
Immunotoxicology (sometimes abbreviated as ITOX) is the study of the toxicity of foreign substances called xenobiotics and their effects on the immune system. [1] Some toxic agents that are known to alter the immune system include: industrial chemicals, heavy metals, agrochemicals, pharmaceuticals, drugs, ultraviolet radiation, air pollutants and some biological materials.
A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their ...