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Acrylamide (or acrylic amide) is an organic compound with the chemical formula CH 2 =CHC (O)NH 2. It is a white odorless solid, soluble in water and several organic solvents. From the chemistry perspective, acrylamide is a vinyl-substituted primary amide (CONH 2).
Glycidamide is a reactive epoxide metabolite from acrylamide [4] [5] and can react with nucleophiles.This results in covalent binding of the electrophile. [6]Glycidamide gives a positive response in the Ames/Salmonella mutagenicity assay, which indicates that it can cause mutations in the DNA. [4]
Budwig protocol (or Budwig diet) – an "anti-cancer" diet developed in the 1950s by Johanna Budwig (1908–2003). The diet is rich in flaxseed oil mixed with cottage cheese, and emphasizes meals high in fruit, vegetables and fiber; it avoids sugar, animal fats, salad oil, meats, butter and especially margarine.
Radiation-induced cognitive decline describes the possible correlation between radiation therapy and cognitive impairment. Radiation therapy is used mainly in the treatment of cancer. Radiation therapy can be used to cure, care or shrink tumors that are interfering with quality of life. Sometimes radiation therapy is used alone; other times it ...
Polyacrylamide is a polyolefin. It can be viewed as polyethylene with amide substituents on alternating carbons. Unlike various nylons, polyacrylamide is not a polyamide because the amide groups are not in the polymer backbone. Owing to the presence of the amide (CONH 2) groups, alternating carbon atoms in the backbone are stereogenic ...
Cancer drugs such as ibrutinib, osimertinib, and rociletinib have an acrylamide functional group as a Michael acceptor. The Michael donor on the drug reacts with a Michael acceptor in the active site of an enzyme. This is a viable cancer treatment because the target enzyme is inhibited following the Michael reaction. [36]
Alkylating antineoplastic agent. An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1) to DNA. [1] Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage—such as being alkylated ...
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. [1] Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, [2] and PARP inhibitors such as olaparib. [3]