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The word liposome derives from two Greek words: lipo ("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.. Liposomes were first described by British hematologist Alec Douglas Bangham [10] [11] [12] in 1961 at the Babraham Institute, in Cambridge—findings that were published 1964.
Alec Douglas Bangham FRS [1] (10 November 1921 Manchester – 9 March 2010 Great Shelford) was a British biophysicist who first studied blood clotting mechanisms but became well known for his research on liposomes and his invention of clinically useful artificial lung surfactants. [2] [3] [4]
Liposomes are ("hollow") lipid nanoparticles which have a phospholipid bilayer as coat, because the bulk of the interior of the particle is composed of aqueous substance. In various popular uses, the optional payload is e.g. DNA vaccines , Gene therapy , vitamins , antibiotics , cosmetics and many others.
Chesebrough opened his first factory in 1870. The first known reference to the name Vaseline is in his U.S. patent: "I, Robert Chesebrough, have invented a new and useful product from petroleum which I have named 'Vaseline…'" . The word is believed to come from German Wasser (water) + Ancient Greek: έλαιον (élaion, oil). [5]
The liposomes were then studied to uncover the properties of biological membranes and a hydration method was discovered to prepare artificial liposomes from 1968 to 1975. [2] Since then, multiple methods of preparing liposomes have been utilized and their characteristics (physical and chemical) have been studied.
Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules. Though liposomes can vary in size from low micrometer range to tens of micrometers, unilamellar liposomes, as pictured here, are typically in the lower size range with various targeting ligands attached to their surface allowing for their surface-attachment and accumulation in ...
Ligand-targeted liposomes are used for a variety of applications depending on the liposome, ligand, and liposome contents. Ligand-targeted liposomes can be used for diagnostics through imaging. The liposomes can contain imaging agents to aid in visualization such as fluorescent dyes, labeling probes, and contrast agents. [15]
Gene therapy is a medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells.