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erythrocytes (red blood cells) at the bottom of the centrifuge tube. Serum separation tubes (SSTs) are tubes used in phlebotomy containing a silicone gel; when centrifuged the silicone gel forms a layer on top of the buffy coat, allowing the blood serum to be removed more effectively for testing and related purposes.
A centrifuge is a device that uses centrifugal force to subject a specimen to a specified constant force - for example, to separate various components of a fluid. This is achieved by spinning the fluid at high speed within a container, thereby separating fluids of different densities (e.g. cream from milk) or liquids from solids.
Therefore, since erythrocytes have the highest specific weight in comparison to other solids in blood, they can easily be separated using centrifugation. Whole blood is spun down in a spinning bowl centrifuge and the bottom layer, concentrated with erythrocytes, sediments to the bottom. These are separated and the rest of the blood can be ...
Continuous flow centrifugation (CFC) historically required two venipunctures as "continuous" means the blood is collected, spun, and returned simultaneously. Newer systems can use a single venipuncture by pooling blood in a vessel and cycling through drawing and returning blood though the needle while the centrifuge continuously processes blood remaining in the vessel. [5]
Blood-spinning is a medical procedure used to shorten the healing time of an injury. Small samples of the patient's blood are taken and spun in a centrifuge , allowing platelets and blood serum to be isolated from other blood components.
Blood plasma fractionation are the general processes separating the various components of blood plasma, which in turn is a component of blood obtained through blood fractionation. Plasma-derived immunoglobulins are giving a new narrative to healthcare across a wide range of autoimmune inflammatory diseases.
Human blood after separation by centrifugation. Plasma (upper layer), buffy coat (middle, white-colored layer) and erythrocyte (red blood cell) layer (bottom) can be seen. The buffy coat is commonly used for DNA extraction, [ 4 ] with leukocytes providing approximately 10 times more concentrated sources of nucleated cells. [ 5 ]
In the chemical and food industries, special centrifuges can process a continuous stream of particle turning into separated liquid like plasma. Centrifugation is also the most common method used for uranium enrichment , relying on the slight mass difference between atoms of U-238 and U-235 in uranium hexafluoride gas.