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Cannabis users have shown decreased reactivity to dopamine, suggesting a possible link to a dampening of the reward system of the brain and an increase in negative emotion and addiction severity. [11] Cannabis users can develop tolerance to the effects of THC. Tolerance to the behavioral and psychological effects of THC has been demonstrated in ...
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Cannabis plants can exhibit wide variation in the quantity and type of cannabinoids they produce. The mixture of cannabinoids produced by a plant is known as the plant's cannabinoid profile. Selective breeding has been used to control the genetics of plants and modify the cannabinoid profile.
Researchers found that 63% of lifetime heavy cannabis-using participants and 68% of recent cannabis users showed reduced brain activity during their working memory task.
Antipsychotics, used to treat psychotic symptoms, such as those associated with schizophrenia or severe mania, or as adjuncts to relieve clinical depression. Mood stabilizers , used to treat bipolar disorder and schizoaffective disorder .
Efforts to isolate the active ingredients in cannabis were made in the 19th century. [86] Cannabidiol was studied in 1940 from Minnesota wild hemp [86] and Egyptian Cannabis indica resin. [87] [88] The chemical formula of CBD was proposed from a method for isolating it from wild hemp. [86] Its structure and stereochemistry were determined in ...