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It is given either by injection into a vein or under the skin. [21] Filgrastim is a leukocyte growth factor. [20] Common side effects include fever, cough, chest pain, joint pain, vomiting, and hair loss. [21] Severe side effects include splenic rupture and allergic reactions. [21] It is unclear if use in pregnancy is safe for the baby. [21]
They are given by injection. [2] Common side effects may include joint pain, rash, vomiting, and headache. [4] Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. [2] It is unclear if use is safe during pregnancy. [5] [6] They work similar to naturally occurring erythropoietin. [1]
The average cost per patient in the US was US$8,447 in 2009. [31] Epoetin alfa has accounted for the single greatest drug expenditure paid by the US Medicare system; in 2010, the program paid US$2 billion for the medication. [32] [33]
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In Canada the total cost of settlements, legal fees, and insurance comes to $4 per person each year, [113] but in the United States it is over $16. Average payouts to American plaintiffs were $265,103, while payouts to Canadian plaintiffs were somewhat higher, averaging $309,417. [ 114 ]
The authors calculated that an annual cost of $4,500 would meet an acceptable $100,000 per QALY standard. [24] On 26 October 2018, the maker of the drug, Amgen , announced a 60% cut in price and the drug at that date cost $5,850 per year.
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