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Ultrasound Doppler imaging can be used to obtain basic functional measurements of brain activity using blood flow. In functional transcranial Doppler sonography, a low frequency (1-3 MHz) transducer is used through the temporal bone window with a conventional pulse Doppler mode to estimate blood flow at a single focal location.
Ultrasound Localization Microscopy (ULM) is an advanced ultrasound imaging technique. By localizing microbubbles, ULM overcomes the physical limit of diffraction, achieving sub-wavelength level resolution and qualifying as a super-resolution technique. [1] [2] ULM is primarily utilized in vascular imaging.
Functional ultrasound imaging (fUS) is a medical ultrasound imaging technique of detecting or measuring changes in neural activities or metabolism, for example, the loci of brain activity, typically through measuring blood flow or hemodynamic changes. Functional ultrasound relies on Ultrasensitive Doppler and ultrafast ultrasound imaging which ...
English: Main brain functional imaging techniques on a three-axis chart (temporal resolution, spatial resolution, portability). Techniques were separated between local and whole-brain imaging. Functional ultrasound fills a gap between whole brain imaging and microscopy, as well as between fMRI and Optics. [1]
Current research in molecular imaging involves cellular/molecular biology, chemistry, and medical physics, and is focused on: 1) developing imaging methods to detect previously undetectable types of molecules, 2) expanding the number and types of contrast agents available, and 3) developing functional contrast agents that provide information ...
The two dimensional image of a point source observed under a microscope is an extended spot, corresponding to the Airy disk (a section of the point spread function) of the imaging system. The ability to identify as two individual entities two closely spaced fluorophores is limited by the diffraction of light.
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Two methods of recording may be used for this procedure. The first uses "B-mode" imaging, which displays a 2-dimensional image of the skull, brain, and blood vessels as seen by the ultrasound probe. Once the desired blood vessel is found, blood flow velocities may be measured with a pulsed Doppler effect probe, which graphs velocities over time.