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  2. Denaturing high performance liquid chromatography - Wikipedia

    en.wikipedia.org/wiki/Denaturing_High...

    Denaturing High Performance Liquid Chromatography (DHPLC) is a method of chromatography for the detection of base substitutions, small deletions or insertions in the DNA. [1]

  3. Reversed-phase chromatography - Wikipedia

    en.wikipedia.org/wiki/Reversed-phase_chromatography

    Silica gel particles are commonly used as a stationary phase in high-performance liquid chromatography (HPLC) for several reasons, [13] [14] including: High surface area: Silica gel particles have a high surface area, allowing direct interactions with solutes or after bonding of variety of ligands for versatile interactions with the sample molecules, leading to better separations.

  4. Verification and validation - Wikipedia

    en.wikipedia.org/wiki/Verification_and_validation

    Verification is intended to check that a product, service, or system meets a set of design specifications. [6] [7] In the development phase, verification procedures involve performing special tests to model or simulate a portion, or the entirety, of a product, service, or system, then performing a review or analysis of the modeling results.

  5. Hydrophilic interaction chromatography - Wikipedia

    en.wikipedia.org/wiki/Hydrophilic_interaction...

    Hydrophilic interaction chromatography (or hydrophilic interaction liquid chromatography, HILIC) [1] is a variant of normal phase liquid chromatography that partly overlaps with other chromatographic applications such as ion chromatography and reversed phase liquid chromatography.

  6. Triple quadrupole mass spectrometer - Wikipedia

    en.wikipedia.org/wiki/Triple_quadrupole_mass...

    Paul Patent 2939952 Fig5. Essentially the triple quadrupole mass spectrometer operates under the same principle as the single quadrupole mass analyzer.Each of the two mass filters (Q1 and Q3) contains four parallel, cylindrical metal rods.

  7. Chiral column chromatography - Wikipedia

    en.wikipedia.org/wiki/Chiral_column_chromatography

    The chiral stationary phase, CSP, can interact differently with two enantiomers, by a process known as chiral recognition. Chiral recognition depends on various interactions such as hydrogen bonding, π-π interaction, dipole stacking, inclusion complexation, steric, hydrophobic and electrostatic interaction, charge-transfer interactions, ionic interactions etc, between the analyte and the CSP ...

  8. Cross-validation (statistics) - Wikipedia

    en.wikipedia.org/wiki/Cross-validation_(statistics)

    Leave-p-out cross-validation (LpO CV) involves using p observations as the validation set and the remaining observations as the training set.This is repeated on all ways to cut the original sample on a validation set of p observations and a training set.

  9. Technology readiness level - Wikipedia

    en.wikipedia.org/wiki/Technology_readiness_level

    Technology readiness levels (TRLs) are a method for estimating the maturity of technologies during the acquisition phase of a program. TRLs enable consistent and uniform discussions of technical maturity across different types of technology. [1]