Search results
Results From The WOW.Com Content Network
In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [ 1 ] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
Clearance is therefore expressed as the plasma volume totally free of the drug per unit of time, and it is measured in units of volume per units of time. Clearance can be determined on an overall, organism level («systemic clearance») or at an organ level (hepatic clearance, renal clearance etc.). The equation that describes this concept is:
In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors.
The term clearance has a general and a specific meaning. In general, clearance refers to the removal of substances from the body. But in renal physiology, clearance specifically refers to the volume of plasma per unit time that is cleared of a particular substance. You're right that it is a rate, but that's just assumed when you say renal ...
Certain emollients, though, have no impact on psoriasis plaque clearance or may even decrease the clearance achieved with phototherapy, e.g. the emollient salicylic acid is structurally similar to para-aminobenzoic acid, commonly found in sunscreen, and is known to interfere with phototherapy in psoriasis.
In clinical studies, metadoxine has been reported to reduce the half-life of ethanol in healthy volunteers and in acutely intoxicated patients; to accelerate the metabolism of alcohol and acetaldehyde into less toxic higher ketones and to improve their urinary clearance; to restore laboratory variables such as alcohol, ammonia, γ-GT, and alanine aminotransferase; and to improve clinical ...
Engineering tolerance, a physical distance or space between two components . Hydraulic clearance, in hydraulic systems; Clearance in civil engineering, including: . The difference between the loading gauge and the structure gauge: the amount of space between the top of a rail car and the top of a tunnel or the bottom of a rail car and the top of rail
What links here; Related changes; Upload file; Special pages; Permanent link; Page information; Cite this page; Get shortened URL; Download QR code