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Renal corpuscle showing glomerulus and glomerular capillaries Figure 2: (a) Diagram of the juxtaglomerular apparatus: it has specialized cells working as a unit which monitor the sodiujuxtaglomerular apparatus: it has three types of specm content of the fluid in the distal convoluted tubule (not labelled - it is the tubule on the left) and adjust the glomerular filtration rate and the rate of ...
The renal corpuscle is composed of two structures, the glomerulus and the Bowman's capsule. [3] The glomerulus is a small tuft of capillaries containing two cell types. . Endothelial cells, which have large fenestrae, are not covered by dia
The podocytes have long primary processes called trabeculae that form secondary processes known as pedicels or foot processes (for which the cells are named podo-+ -cyte). [2] The pedicels wrap around the capillaries and leave slits between them. Blood is filtered through these slits, each known as a filtration slit, slit diaphragm, or slit ...
Most often, it is dependent on what part of the glomerulus is damaged by antibody-antigen complex (immune complex) deposition. [9] In all cases, however, the inflammatory processes in the glomerulus cause the capillaries to swell and the pores between podocytes become large enough that inappropriate contents in the blood plasma (i.e. red blood ...
[9] [10] Concurrently, there are changes within the glomerulus itself: these include a thickening of the basement membrane, a widening of the slit membranes of the podocytes, an increase in the number of mesangial cells, and an increase in mesangial matrix. This matrix invades the glomerular capillaries and produces deposits called Kimmelstiel ...
Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [4] Central to the physiologic maintenance of GFR is the differential basal tone of the afferent (input) and efferent (output) arterioles (see diagram).
A glomerulus, a functional unit that represents the first step in the filtration of blood and generation of urine. Glomerulonephritis refers to an inflammation of the glomerulus, which is the unit involved in filtration in the kidney. This inflammation typically results in one or both of the nephrotic or nephritic syndromes. [2]: 500
A healthy glomerulus allows many solutes in the blood to pass through, but does not permit the passage of cells or high-molecular weight substances such as most proteins. The filtrate from the glomerulus enters the capsule and proceeds to the renal tubules , which reabsorb water and solutes from the filtrate into the circulation and secrete ...