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A systematic review from 2016 found that metamizole significantly increased the relative risk of upper gastrointestinal bleeding, by a factor of 1.4–2.7 times. [31] A study by one of the manufacturers of the drug found the risk of agranulocytosis within the first week of treatment to be a 1.1 in a million, [32] versus 5.9 in a million for ...
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. [1]
[1] [8] The underlying mechanism involves blockage of dopamine receptors. [1] Diagnosis is based on symptoms. [2] Management includes stopping the triggering medication, rapid cooling, and starting other medications. [2] Medications used include dantrolene, bromocriptine, and diazepam. [2] The risk of death among those affected is about 10%. [4]
Evans syndrome is an autoimmune disease in which an individual's immune system attacks their own red blood cells and platelets, the syndrome can include immune neutropenia. [1] [2] These immune cytopenias may occur simultaneously or sequentially. [1] [3]
Leukopenia – a deficiency of white blood cells, or leukocytes [1] Neutropenia – a type of leukopenia, with a specific deficiency in neutrophils [2] Thrombocytopenia – a deficiency of platelets; Pancytopenia – when all three types of blood cells; red blood cells, white blood cells, and platelets, are all deficient.
Along with Döhle bodies and toxic vacuolation, which are two other findings in the cytoplasm of granulocytes, toxic granulation is a peripheral blood film finding suggestive of an inflammatory process. [1] Toxic granulation is often found in patients with bacterial infection and sepsis, [1] [2] although the finding is nonspecific. [3]
Granulocytosis can be a feature of a number of diseases, including: [citation needed] Infection, especially bacterial; Malignancy, most notably leukemia (it is the main feature of chronic myelogenous leukemia, CML) Autoimmune disease
Efbemalenograstim alfa, sold under the brand name Ryzneuta, is a medication used to decrease the incidence of infection in chemotherapy-induced neutropenia. [1] It is a leukocyte growth factor. [1] It is given by subcutaneous injection. [1] The most common side effects of efbemalenograstim alfa are nausea, anemia, and thrombocytopenia. [5]