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Although H. pylori infection can cause gastrointestinal metaplasia, its eradication does not reverse the process. [1] Bile reflux is an additional pathogenic factor in gastrointestinal metaplasia that can continuously irritate the gastric mucosa. Bile acids in refluxed fluid are widely reported to be associated with gastrointesinal metaplasia ...
The presence of intestinal metaplasia in Barrett's esophagus represents a marker for the progression of metaplasia towards dysplasia and eventually adenocarcinoma. This factor combined with two different immunohistochemical expression of p53, Her2 and p16 leads to two different genetic pathways that likely progress to dysplasia in Barrett's ...
Pancreatic acinar metaplasia; Micrograph of a gastro-esophageal junction with pancreatic acinar metaplasia. The esophageal mucosa (stratified squamous epithelium) is seen on the right. The gastric mucosa (simple columnar epithelium) is seen on the left.
Metaplasia; Micrograph of a gastro-esophageal junction with pancreatic acinar metaplasia. The esophageal mucosa (stratified squamous epithelium) is seen on the right. The gastric mucosa (simple columnar epithelium) is seen on the left. The metaplastic epithelium is at the junction (center of image) and has an intensely eosinophilic (bright pink ...
Barrett's esophagus – intestinal metaplasia (changes of the epithelial cells from squamous to intestinal columnar epithelium) of the distal esophagus [20] Esophageal adenocarcinoma – a form of cancer [17] GERD sometimes causes injury of the larynx (LPR). [21] [22] Other complications can include aspiration pneumonia. [23]
The mucosa is the innermost layer of the gastrointestinal tract. It surrounds the lumen of the tract and comes into direct contact with digested food ( chyme ). The mucosa itself is made up of three layers: [ 1 ] the epithelium , where most digestive, absorptive and secretory processes occur; the lamina propria , a layer of connective tissue ...
The narrowing is caused by a ring of mucosal tissue (which lines the esophagus) or muscular tissue. [1] A Schatzki ring is a specific type of "esophageal ring", and Schatzki rings are further subdivided into those above the esophagus / stomach junction (A rings), [ 2 ] and those found at the squamocolumnar junction in the lower esophagus (B rings).
Glandular metaplasia is a type of metaplasia where irritated tissue converts to a glandular form. An example occurs in the esophagus , where tissue becomes more similar to the tissue of the stomach .