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[28] [16] In addition, the AR antagonism of spironolactone is involved in its feminizing side effects, such as gynecomastia in men. [28] Spironolactone has been found to produce gynecomastia without changes in testosterone or estradiol levels, implicating AR antagonism in this side effect. [30] Gynecomastia is a major known side effect of AR ...
High doses of spironolactone, which are needed for considerable antiandrogenic effects, are not recommended for men due to the high risk of feminization and other side effects. Spironolactone can be used to treat symptoms of hyperandrogenism , such as due to polycystic ovary syndrome .
5α-Reductase inhibitors have minimal side effects and are well tolerated in both men and women. [219] [220] In men, the most common side effect is sexual dysfunction (0.9–15.8% incidence), which may include decreased libido, erectile dysfunction, and reduced ejaculate.
Spironolactone: Spironolactone is ... Its effects on hormones are so pronounced that it is not recommended for treating acne in men because of its potentially feminizing side effects.
Gender-affirming hormone therapy (GAHT), also called hormone replacement therapy (HRT) or transgender hormone therapy, is a form of hormone therapy in which sex hormones and other hormonal medications are administered to transgender or gender nonconforming individuals for the purpose of more closely aligning their secondary sexual characteristics with their gender identity.
As the masculinizing effects of testosterone is limited in AIS, DHT more easily binds to androgen receptors and cannot be directly converted into estrogen via the androgen backdoor pathway, this is useful as an androgen treatment for AIS as testosterone can often result in unintentional feminizing effects such as breast growth and hip widening.
There have been reports that their effects can last for days or weeks at a time. While you might want to last longer in bed, this isn’t a good thing. There are other risks and adverse events ...
Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Everything I Wish I Knew About ...