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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
In Europe, M. m. domesticus lives in Western and Southern Europe, while another subspecies, the Eastern European house mouse (M. m. musculus) lives in Eastern and Northern Europe. [2] The area from Scandinavia to the Black Sea is a secondary hybrid zone for M. m. domesticus and M. m. musculus . [ 3 ]
In 1921, C57BL became one of the most widely used mice in genetics and was the first strain to have its genome sequenced. In 1982, Palmiter and Brinster implanted a foreign gene into fertilized egg , finally generating the first transgenic mice genetically engineered to express dominant oncogenes.
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
The researchers performed a variety of tests and found that the microplastic-exposed mice started exhibiting signs of cognitive decline similar to dementia. “I didn’t really think we were ...
Doug Corwin, owner of Crescent Duck Farm, carries a female duck used for breeding in 2014 in Aquebogue, New York. Millions of birds have been killed in response to the spread of H5N1 bird flu.
Navelbine and carboplatin, two chemotherapeutics currently on the market, were tested in C57BL mice with Lewis lung carcinoma tumors in their hind flank. Tumor regression reached 72.7% in the navelbine trials, with the carboplatin trials showing that 30-50 percent of the population had a prolonged tumor survival after treatment with carboplatin ...
Fatty acids change how genes work. The researchers found that both propionate and butyrate altered gene expression in several isolated human cell types: healthy cells and treated colon cancer cells.