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The primary histological characteristics include profound neuronal loss, enlarged neurons, and distinctive spherical argyrophilic inclusions known as Pick bodies (PBs). These PBs primarily consist of hyperphosphorylated tau protein, with tau protein presenting as two major bands at 60 and 64 kDa and a variable, minor band at 69 kDa.
Using those methods, they contributed extensively to the neuropathology of Alzheimer's and Parkinson's diseases. In 1987, Braak and her husband were the first to describe the pathological changes of argyrophilic grain disease, an unknown tauopathy which was previously marked as senile dementia. [4]
A similar classification was proposed in 2003 for the pathoanatomical changes associated with idiopathic Parkinson's disease. [6] Braak and his wife, Eva Braak, were the first to describe the pathological changes of argyrophilic grain disease, a previously unknown form of senile dementia. [7]
Various forms of tauopathies (e.g. Pick's disease, Progressive supranuclear palsy, Corticobasal degeneration, Frontotemporal dementia with parkinsonism linked to chromosome 17, Argyrophilic grain disease) ATau Huntingtin exon 1 [20] [21] Huntington's disease: HTTex1 ABri peptide: Familial British dementia: ABri ADan peptide: Familial Danish ...
The doctor also warned of red meat potentially leading to weight gain and obesity, which can cause inflammation and in turn raise the risk of dementia. "Red meat may also lead to heart disease ...
Red meat has a high amount of saturated fat and yields an organic compound linked to cardiovascular disease, ... It focuses on eating fruits, vegetables, grains, olive oil, nuts and seeds, and the ...
Legumes, whole grains and nonstarchy vegetables are excellent sources of plant-based protein and fiber. According to the American Diabetes Association, foods high in fiber—like whole grains and ...
Viral diseases; African cereal streak see Maize streak Agropyron mosaic genus Rymovirus, Agropyron mosaic virus (AgMV) Australian wheat striate mosaic