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Among Ashkenazi Jews, a higher incidence of specific genetic disorders and hereditary diseases has been verified, including: Alport syndrome [30] Colorectal cancer due to hereditary nonpolyposis colorectal cancer [31] Congenital adrenal hyperplasia (nonclassical form) [32] Congenital insensitivity to pain with anhidrosis [33]
Healthcare professionals are often taught to consider those of Ashkenazi descent to be at increased risk for colon cancer. [193] People of Ashkenazi descent are at much higher risk of being a carrier for Tay–Sachs disease, which is fatal in its homozygous form. [194]
They are removed because of their tendency to become malignant and to lead to colon cancer. Ashkenazi Jews have a 6% higher risk rate of getting adenomas, and then colon cancer, than do the general population, so it is important that they have regular actual colonoscopies, and specifically none of the less invasive diagnostic methods.
The Program for Jewish Genetic Health offers educational programs – both live and online – to various sectors of the community to educate them on Jewish genetic health issues, including the Ashkenazi Jewish link to breast and ovarian cancer, Parkinson's disease, and prostate cancer, as well as alternative family planning options such as pre-implantation genetic diagnosis.
Hereditary breast, ovarian and melanoma cancer rates are particularly acute in Ashkenazi Jewish populations in Israel [3] (31.8% of Israeli Jews), in-part due to a higher-prevalence of BRCA and BRCA2 mutations (1 in 40 vs 1 in 400 in most populations worldwide) in Ashkenazi Jewish populations, [4] which increase the likelihood of hereditary ...
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
Epigenetic factors, such as abnormal DNA methylation of tumor suppressor promoters, play a role in the development of colorectal cancer. [44] Ashkenazi Jews have a 6% higher risk rate of getting adenomas and then colon cancer due to mutations in the APC gene being more common. [45]
Kenneth Offit (born February 19, 1955) is an American cancer geneticist and oncologist known for his discoveries with respect to the genetic bases of breast, colorectal, and lymphoid cancers. [1] He is currently Chief of the Clinical Genetics Service and the Robert and Kate Niehaus Chair in Inherited Cancer Genomics at Memorial Sloan Kettering ...