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Histopathology of NIFTP, H&E stain. [1]Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, [2] necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, [2] and may ...
Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. [1] The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary ...
Papillary microcarcinoma is a subset of papillary thyroid cancer defined as measuring less than or equal to 1 cm. [15] The highest incidence of papillary thyroid microcarcinoma in an autopsy series was reported by Harach et al. in 1985, who found 36 of 101 consecutive autopsies to have an incidental microcarcinoma. [16]
Hobnail variant of PTC combining papillary (d), and micropapillary (e) structures lined by hobnail cells. “Teardrop” cells (f) and comet-like cells (inset). The cribriform-morular thyroid carcinoma exhibits a blending of cribriform, papillary, trabecular, and solid pattern with morules (g) and (h). Morules are strongly positive for CD10 (i).
A papillary tumor is a tumor shaped like a small mushroom, with its stem attached to the epithelial layer (inner lining) of an organ. [1] [2] It consists of papillae, which are outgrowths that consist of stroma with at least one central blood vessel, surrounded by epithelium. Usually, the epithelium constitutes the true tumor cells, and the ...
Hürthle cell carcinomas are characterized as either minimally invasive or widely invasive tumors. While the minimally invasive or encapsulated carcinoma is fully surrounded by a fibrous capsule, the widely invasive carcinoma shows extensive area of both capsular and vascular invasion with the leftover capsule typically difficult to identify. [6]
Nuclear grooves (arrows indicate one of them) in papillary thyroid cancer. H&E stain. Cytopathology of papillary thyroid carcinoma, with typical features, with nuclear groove at bottom right. Pap stain. A nuclear groove is an invagination of the nuclear envelope, in the longitudinal axis. [1] It can be present in:
The diagnosis of PB may be suggested in individuals with the clinical presentation of PB plus the presence of a family history of mammary secretory carcinomas, lobular carcinoma, ductal carcinoma in situ, invasive ductal carcinomas of no special type, [4] [5] [14] Cowden disease, Noonan syndrome, Proteus syndrome, or neurofibromatosis type 1.