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Depiction of a red blood cell in an isotonic solution. A solution is isotonic when its effective osmole concentration is the same as that of another solution. In biology, the solutions on either side of a cell membrane are isotonic if the concentration of solutes outside the cell is equal to the concentration of solutes inside the cell.
The crab-eating frog, or Rana cancrivora, is an example of a vertebrate osmoconformer. The crab-eating frog also regulates its rates of urea retention and excretion, which allows them to survive and maintain their status as osmoconformers in a wide range of external salinities. [ 3 ]
The science of fluid balance across fluid compartments has practical application in intravenous therapy, where doctors and nurses must predict fluid shifts and decide which IV fluids to give (for example, isotonic versus hypotonic), how much to give, and how fast (volume or mass per minute or hour).
The term isotonic may refer to: Isotonic (exercise physiology), a type of muscle contraction; Isotonic regression, a type of numerical analysis; Isotonic, one of three types of tonicity that characterize a solution's concentration; see Tonicity#Isotonicity; A sports drink that contains similar concentrations of salt and sugar to the human body
A solution can be both hyperosmotic and isotonic. [2] For example, the intracellular fluid and extracellular can be hyperosmotic, but isotonic – if the total concentration of solutes in one compartment is different from that of the other, but one of the ions can cross the membrane (in other words, a penetrating solute), drawing water with it ...
Osmoregulation is the active regulation of the osmotic pressure of an organism's body fluids, detected by osmoreceptors, to maintain the homeostasis of the organism's water content; that is, it maintains the fluid balance and the concentration of electrolytes (salts in solution which in this case is represented by body fluid) to keep the body fluids from becoming too diluted or concentrated.
Ringer's solution is a solution of several salts dissolved in water for the purpose of creating an isotonic solution relative to the body fluids of an animal. Ringer's solution typically contains sodium chloride , potassium chloride , calcium chloride and sodium bicarbonate , with the last used to buffer the pH .
Thus, a biologically isotonic solution (e.g. "isotonic saline") is hyposmotic (osmolality = 287 mosmol/kg H20) with respect to blood plasma (301 mosmol/kg H20) or the interior of red blood cells, because both these solutions (blood plasma and red cell cytoplasm) contain urea, glucose and bicarbonate which pass freely through the cell membrane.