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Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe kidney failure, hepatic encephalopathy or severe liver failure, and a low blood potassium level. [citation needed] There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding. [citation needed]
Using a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium ...
Thiazides combined with potassium citrate, increased water intake and decreased dietary oxalate and sodium can slow or even reverse the formation of calcium-containing kidney stones. [18] High-dose therapy with the thiazide-like diuretic indapamide can be used to treat idiopathic hypercalcinuria (high urine calcium with unknown cause). [19]
The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of calcium. [5] The reduced concentration of calcium in the urine can lead to an increased rate of calcium in serum. The sparing effect on calcium can be beneficial in hypocalcemia, or unwanted in hypercalcemia. [citation ...
Sodium reabsorption also causes water retention. [8] [9] When the kidneys detect low blood pressure, the renin–angiotensin–aldosterone system (RAAS) is activated and eventually, aldosterone is secreted. Aldosterone binds to aldosterone receptors (mineralocorticoid receptors) increasing sodium reabsorption in an effort to increase blood ...
Lifestyle changes can stop prediabetes in its tracks. You may be able to delay the onset of type 2 diabetes or prevent it entirely. Prediabetes is common — it affects about one in three people .
Examples include metolazone, chlorthalidone, and indapamide. [1] References This page was last edited on 4 May 2022, at 02:01 (UTC). Text is available under ...
Poison Profits. A HuffPost / WNYC investigation into lead contamination in New York City