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Pedicels of podocytes interdigitating to create numerous filtration slits around glomerular capillaries in 5000x electron micrograph. Podocytes secrete and maintain the basement membrane. [3] There are numerous coated vesicles and coated pits along the basolateral domain of the podocytes which indicate a high rate of vesicular traffic.
An illustration of podocytes, which surround the glomerular capillaries with their cell bodies, primary processes and interdigitating foot processes. The podocyte is a highly specialised epithelial cell in Bowman's capsule in the kidney. Primary processes of the podocytes form terminal foot processes.
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. [1] It is a member of the CD34 family of transmembrane sialomucins. [2] It coats the secondary foot processes of the podocytes.
Filtration barrier—The filtration barrier is composed of the fenestrated endothelium of the glomerular capillaries, the fused basal lamina of the endothelial cells and podocytes, and the filtration slits of the podocytes. The barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space.
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Hints and the solution for today's Wordle on Tuesday, February 4.