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The urea breath test is a rapid diagnostic procedure used to identify infections by Helicobacter pylori, a spiral bacterium implicated in gastritis, gastric ulcer, and peptic ulcer disease. It is based upon the ability of H. pylori to convert urea to ammonia and carbon dioxide.
Rapid urease test, also known as the CLO test (Campylobacter-like organism test), is a rapid diagnostic test for diagnosis of Helicobacter pylori. [1] The basis of the test is the ability of H. pylori to secrete the urease enzyme, which catalyzes the conversion of urea to ammonia and carbon dioxide.
Carbon urea breath tests have a high sensitivity and specificity for the diagnosis of H. pylori. [ 136 ] Proton-pump inhibitors and antibiotics should be discontinued for at least 30 days prior to testing for H. pylori infection or eradication, as both agents inhibit H. pylori growth and may lead to false negative results. [ 135 ]
The presence of Helicobacter pylori (in peptic ulcer disease) can be tested for with the urea breath test. Exhaled nitric oxide is a breath test that might signal airway inflammation such as in asthma. Breath tests for diseases have been developed for early detection of lung cancer, breast cancer, pulmonary tuberculosis and many others, to ...
A second generation product, BreathID Hp Breath Test System, received an EU CE Mark on April 18, 2013, and FDA clearance on May 22, 2013. [3] The BreathID Hp Breath Test System is used to perform a diagnostic test for the presence of Helicobacter pylori, a bacterium that can cause peptic ulcers and is associated with gastric cancer. [4]
The success of H. pylori cure depends on the type and duration of therapy, patient compliance and bacterial factors such as antibiotic resistance. Patients most often fail to respond to initial H. pylori eradication therapy because of noncompliance or antibiotic resistance. Patients should be queried about any side effects, missed doses, and ...