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Medications to treat the toxic effects include: intravenous fluids, calcium gluconate, glucagon, high dose insulin, vasopressors and lipid emulsion. [1] [2] Extracorporeal membrane oxygenation may also be an option. [1] More than ten thousand cases of calcium channel blocker toxicity were reported in the United States in 2010. [2]
Initial treatment of exposure involves removing contaminated clothing and washing the affected area with large amount of water over at least 30 minutes. [1] Calcium gluconate cream is then usually applied. [1] If pain continues calcium gluconate can be injected into the affected area or given by injection into a vein or artery. [2]
10% calcium gluconate solution (given intravenously) is the form of calcium most widely used in the treatment of low blood calcium.This form of calcium is not as well absorbed as calcium lactate, [12] and it only contains 0.93% (93 mg/dL) calcium ion (defined by 1 g weight solute in 100 mL of solution to make 1% solution w/v).
Adenosine receptor agonist poisoning Antimuscarinic drugs (e.g. Atropine) Organophosphate and carbamate insecticides, nerve agents, some poison mushrooms: Beta blocker: Theophylline: Calcium chloride [7] Calcium channel blocker toxicity, [7] black widow spider bites Calcium gluconate [7] Calcium channel blocker toxicity, [7] hydrofluoric acid burns
Treatment involves stopping the magnesium a person is getting. [2] Treatment when levels are very high include calcium chloride, intravenous normal saline with furosemide, and hemodialysis. [1] Hypermagnesemia is uncommon. [3] Rates among hospitalized patients in renal failure may be as high as 10%. [2]
Intravenous calcium gluconate (or calcium chloride if a central line is available) and atropine are first-line therapies. If the time of the overdose is known and presentation is within two hours of ingestion , activated charcoal , gastric lavage , and polyethylene glycol may be used to decontaminate the gut.
Administration of intravenous sodium bicarbonate as an antidote has been shown to be an effective treatment for resolving the metabolic acidosis and cardiovascular complications of TCA poisoning. If sodium bicarbonate therapy fails to improve cardiac symptoms, conventional antidysrhythmic drugs or magnesium can be used to reverse any cardiac ...
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML [1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. [2]