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Signs and symptoms of pregnancy are common, benign conditions that result from the changes to the body that occur during pregnancy. Signs and symptoms of pregnancy typically change as pregnancy progresses, although several symptoms may be present throughout. Depending on severity, common symptoms in pregnancy can develop into complications ...
HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. [33] Twelve months of trastuzumab therapy is optimal.
Medical providers often struggle to 'rule out' pregnancy for medical testing or treatment that cannot be conducted during pregnancy before they can do an accurate urine pregnancy test. [ 27 ] More rare, false negative results can also occur due to a " hook effect ", where a sample with a very high level of hCG is tested without dilution ...
Signs and symptoms of early pregnancy may include missed periods, tender breasts, morning sickness (nausea and vomiting), hunger, implantation bleeding, and frequent urination. [1] Pregnancy may be confirmed with a pregnancy test. [7] Methods of birth control—or, more accurately, contraception—are used to avoid pregnancy.
During my 36th week of pregnancy, more symptoms began to develop. During this week, I felt even more worn out than in previous weeks. I checked my blood pressure: 146/84.
Cervix with a bluish-violet discolouration. Chadwick sign is a medical clinical sign characterised by the bluish-violet discolouration of the mucous membranes of the vulva, vagina (particularly on the anterior vaginal wall), and the cervix, resulting from venous congestion due to increased blood flow as part of the maternal physiological changes in pregnancy.
The HER2 gene (also known as HER2/neu and ErbB2 gene) is amplified in 20–30% of early-stage breast cancers. [43] Trastuzumab is a monoclonal antibody targeting HER2, inducing an immune-mediated response that causes internalization and recycling of HER2. It may also upregulate cell cycle inhibitors such as p21 Waf1 and p27 Kip1. [57]
Urine-based pregnancy tests detect hCG in the urine, while blood-based pregnancy tests measure the level of hCG in the blood. [5] The presence of hCG in a woman's body indicates that a fertilized egg has implanted in the uterus and the placenta has started to form. 10 days after fertilization, significant hCG can be detected from woman's blood ...