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Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
The company sells various pharmaceuticals for common pets and farm animals – mainly for dogs, cats, equine and food producing animals. Their notable products include Vetoryl, a medicine for Cushing's disease in dogs, and Felimazole, medicine for hyperthyroidism in cats. The company is organised into two regional divisions: European ...
Trilostane, sold under the brand name Vetoryl, inhibits the 3-beta-hydroxysteroid dehydrogenase enzyme. The enzyme is responsible for the production of cortisol and the inhibition of it will inhibit cortisol production. Trilostane has been identified by multiple studies as an effective treatment for Cushing's.
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]
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This list of dog diseases is a selection of diseases and other conditions found in the dog.Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans.