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The system is based on the expression of two codominant alleles, designated Lua and Lub. The antigens Aua and Aub, known as the Auberger antigens, were once thought to make up a separate blood group but were later shown to be Lutheran antigens arising from variations in the BCAM gene. The phenotypes Lu(a+b−) and Lu(a+b+) are found at various ...
4059 57278 Ensembl ENSG00000187244 ENSMUSG00000002980 UniProt P50895 Q9R069 RefSeq (mRNA) NM_005581 NM_001013257 NM_020486 RefSeq (protein) NP_001013275 NP_005572 NP_065232 Location (UCSC) Chr 19: 44.81 – 44.82 Mb Chr 7: 19.49 – 19.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that ...
The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...
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Depending upon a person's ABO blood type, the H antigen is converted into either the A antigen, B antigen, or both. If a person has group O blood, the H antigen remains unmodified. Therefore, the H antigen is present more in blood type O and less in blood type AB. Hh antigen system - diagram showing the molecular structure of the ABO(H) antigen ...
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.
The LW blood system was first described by Landsteiner and Wiener in 1940. [1] It was often confused with the Rh system, not becoming a separate antigen system until 1982. The LW and RhD antigens are genetically independent though they are phenotypically related and the LW antigen is expressed more strongly on RhD positive cells than on RhD negative cells.
The Rh blood group system is a human blood group system. It contains proteins on the surface of red blood cells. After the ABO blood group system, it is most likely to be involved in transfusion reactions. The Rh blood group system consisted of 49 defined blood group antigens [1] in 2005.