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The system is based on the expression of two codominant alleles, designated Lua and Lub. The antigens Aua and Aub, known as the Auberger antigens, were once thought to make up a separate blood group but were later shown to be Lutheran antigens arising from variations in the BCAM gene. The phenotypes Lu(a+b−) and Lu(a+b+) are found at various ...
4059 57278 Ensembl ENSG00000187244 ENSMUSG00000002980 UniProt P50895 Q9R069 RefSeq (mRNA) NM_005581 NM_001013257 NM_020486 RefSeq (protein) NP_001013275 NP_005572 NP_065232 Location (UCSC) Chr 19: 44.81 – 44.82 Mb Chr 7: 19.49 – 19.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that ...
The LW blood system was first described by Landsteiner and Wiener in 1940. [1] It was often confused with the Rh system, not becoming a separate antigen system until 1982. The LW and RhD antigens are genetically independent though they are phenotypically related and the LW antigen is expressed more strongly on RhD positive cells than on RhD negative cells.
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The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...
Auberger's blood group is a type of human blood group [1] in which the Aua antigen is expressed. It is found in 82% of caucasians. It may be related to the Lutheran antigen system. [citation needed] The blood group was named after patient Auberger, who was a 59-year-old French woman with oesophageal varices. [citation needed]
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.
The Ii antigen system is a human blood group system based upon a gene on chromosome 6 and consisting of the I antigen and the i antigen. [1] The I antigen is normally present on the cell membrane of red blood cells in all adults, while the i antigen is present in fetuses and newborns. [2]