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The hormone gastrin and the vagus nerve trigger the release of both pepsinogen and HCl from the stomach lining when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin (the active form). Pepsin cleaves the 44 amino acids ...
2695 14607 Ensembl ENSG00000159224 ENSMUSG00000014351 UniProt P09681 P48756 RefSeq (mRNA) NM_004123 NM_008119 RefSeq (protein) NP_004114 NP_032145 Location (UCSC) Chr 17: 48.96 – 48.97 Mb Chr 11: 95.92 – 95.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Gastric inhibitory polypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone ...
Getting a diabetes test can help you get a proper diagnosis. Here, doctors explain how to test for diabetes, gestational diabetes tests, general A1C, and more.
Chief cells are part of fundic gland polyps (here shown in high magnification). [11]In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia (SPEM ...
It is produced in the stomach by gastric chief cells in its inactive form pepsinogen, which is a zymogen. Pepsinogen is then activated by the stomach acid into its active form, pepsin. Pepsin breaks down the protein in the food into smaller particles, such as peptide fragments and amino acids.
Gastric acid or stomach acid is the acidic component – hydrochloric acid of gastric juice, produced by parietal cells in the gastric glands of the stomach lining. In humans, the pH is between one and three, much lower than most other animals, but is very similar to that of carrion eating carnivores, needing protection from ingesting pathogens ...
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